Mass Spectrometry Quiz

1.
Who made molecular elephants fly?
- John B. Fenn
- Joseph J. Thomson
- W. and O. Wright
Your answer:

Correct answer:

John Fenn was awarded Nobel Prize in Chemistry in 2002 for his work related to electrospray ionization of biological macromolecules. His famous phrase, "we made elephants fly" refers to the ability of electrospray to generate gas-phase ions from big protein molecules.
2.
List these compounds according to their increasing mass: hydrazine (H4N2), oxygen (O2), methanol (CH4O).
- Hydrazine, oxygen, methanol
- Methanol, hydrazine, oxygen
- Oxygen, methanol, hydrazine
Your answer:

Correct answer:

The monoisotopic masses of these compounds are 31.989829 Da (oxygen), 32.026215 Da (methanol), and 32.037448 Da (hydrazine).
3.
The quadrupole mass filter has been known since the mid-1950s thanks to the work of Wolfgang Paul. The motion of ions in a quadrupole field can be described by solving second-order differential equations. When were these equations solved mathematically?
- 1868
- 1968
- 1989
Your answer:

Correct answer:

The solution of differential equations of this type came from the French mathematician Émile Léonard Mathieu (1835-1890), who studied the mechanical vibrations of the elliptical drumheads.
4.
Which element has the largest number of stable isotopes?
- Molybdenum
- Tin
- Ytterbium
Your answer:

Correct answer:

Naturally occurring tin is a mixture of its ten stable isotopes and they are found in the percentages as follows: ¹¹²Sn (1.0 %), ¹¹⁴Sn (0.7 %), ¹¹⁵Sn (0.3 %), ¹¹⁶Sn (14.5 %), ¹¹⁷Sn (7.7 %), ¹¹⁸Sn (24.2 %), ¹¹⁹Sn (8.6 %), ¹²⁰Sn (32.6 %), ¹²²Sn (4.6 %), and ¹²⁴Sn (5.8 %). Molybdenum has six stable isotopes, ytterbium seven.
5.
John Zeleny was an American physicist whose work laid the theoretical foundations of electrospray ionization. He was born in 1872 into a family of immigrants from Europe. Where did his family come from?
- Slovakia
- Czechia
- Poland
Your answer:

Correct answer:

The parents of John Zelený, Antonín Zelený and Josefa Pitková, came from Křídla, a small village near Žďár nad Sázavou in Austria-Hungary (now the Czech Republic).
6.
Which mass spectrometer was carried by the American spacecraft Viking 1 sent to the planet Mars in 1975?
- Double-focusing mass spectrometer
- Time-of-flight mass spectrometer
- Quadrupole mass spectrometer
Your answer:

Correct answer:

Viking 1 carried two mass spectrometers, both equipped with double-focusing analyzers and electron ionization sources. The first spectrometer with a Mattauch-Herzog geometry was designed by Alfred Nier; it was intended to analyze the upper atmosphere of Mars. The second one with a Nier- Johnson geometry was part of the GC/MS apparatus designed by Klaus Biemann. It was used to analyze the regolith and the atmosphere at the landing site.
7.
How long would be a paper needed for printing a profile mass spectrum measured in the m/z 0 1000 range at a resolution of 50,000 at m/z 500 if the peaks were to be 1 mm wide at their half maximum? Let us consider a constant width of all peaks.
- 1 m
- 10 m
- 100 m
Your answer:

Correct answer:

The resolution can be expressed as (m/z)/Δ(m/z), where Δ (m/z) is the peak width at 50 % of its maximum. For a resolution of 50,000 at m/z 500, the value of Δ(m/z) is 0.01. If the Δ(m/z) is to correspond to 1 mm, then the total width of the spectral record equals 1000/0.01 mm, which is 100,000 mm, which is 100 m.
8.
Lunar craters are usually named after scientists and explorers. One of the craters on the Moon is named after a prominent scientist in the field of mass spectrometry. Who is named after?
- Francis William Aston
- Wolfgang Paul
- John Bennett Fenn
Your answer:

Correct answer:

Aston is a 44-kilometer lunar impact crater located along the northwestern limb of the Moon. The crater was named in honor of Francis W. Aston.
9.
Who first reported the fragmentation after the gamma hydrogen rearrangement to an unsaturated group via a sixmembered intermediate?
- A. J. C. Nicholson
- F. W. McLafferty
- F. Tureček
Your answer:

Correct answer:

It was first reported by Australian A. J. C. Nicholson in 1954 (Trans. Faraday Soc. 50: 1067-1073). The reaction description was published five years later (Anal. Chem. 1959, 31: 82–87) by the American chemist Fred McLafferty, by whose name we now refer to the rearrangement (McLafferty rearrangement).
10.
The first on-line coupling of gas chromatography to a mass spectrometer was reported in 1959. What type of spectrometer was used for this purpose?
- Double-focusing mass spectrometer
- Time-of-flight mass spectrometer
- Quadrupole mass spectrometer
Your answer:

Correct answer:

The first GC/MS experiments were carried out by Fred McLafferty and Roland Gohlke at Dow Chemical with Bill Wiley and Ian McLaren at Bendix Research Laboratories. They used a Bendix timeof- flight mass spectrometer, which had been commercially introduced in 1956. The instrument was fast enough to keep up with the changing output of the GC column.

Mass Spectrometry Quiz

Mass Spectrometry Quiz

Thank you for taking our quiz!

1.
Who made molecular elephants fly?

2.
List these compounds according to their increasing mass: hydrazine (H4N2), oxygen (O2), methanol (CH4O).

3.
The quadrupole mass filter has been known since the mid-1950s thanks to the work of Wolfgang Paul. The motion of ions in a quadrupole field can be described by solving second-order differential equations. When were these equations solved mathematically?

4.
Which element has the largest number of stable isotopes?

5.
John Zeleny was an American physicist whose work laid the theoretical foundations of electrospray ionization. He was born in 1872 into a family of immigrants from Europe. Where did his family come from?

6.
Which mass spectrometer was carried by the American spacecraft Viking 1 sent to the planet Mars in 1975?

7.
How long would be a paper needed for printing a profile mass spectrum measured in the m/z 0 1000 range at a resolution of 50,000 at m/z 500 if the peaks were to be 1 mm wide at their half maximum? Let us consider a constant width of all peaks.

8.
Lunar craters are usually named after scientists and explorers. One of the craters on the Moon is named after a prominent scientist in the field of mass spectrometry. Who is named after?

9.
Who first reported the fragmentation after the gamma hydrogen rearrangement to an unsaturated group via a sixmembered intermediate?

10.
The first on-line coupling of gas chromatography to a mass spectrometer was reported in 1959. What type of spectrometer was used for this purpose?

Czech Museum
of Mass Spectrometry

Our partners

Mass Spectrometry Quiz

Mass Spectrometry Quiz

Thank you for taking our quiz!

1. Who made molecular elephants fly?

2. List these compounds according to their increasing mass: hydrazine (H4N2), oxygen (O2), methanol (CH4O).

3. The quadrupole mass filter has been known since the mid-1950s thanks to the work of Wolfgang Paul. The motion of ions in a quadrupole field can be described by solving second-order differential equations. When were these equations solved mathematically?

4. Which element has the largest number of stable isotopes?

5. John Zeleny was an American physicist whose work laid the theoretical foundations of electrospray ionization. He was born in 1872 into a family of immigrants from Europe. Where did his family come from?

6. Which mass spectrometer was carried by the American spacecraft Viking 1 sent to the planet Mars in 1975?

7. How long would be a paper needed for printing a profile mass spectrum measured in the m/z 0 1000 range at a resolution of 50,000 at m/z 500 if the peaks were to be 1 mm wide at their half maximum? Let us consider a constant width of all peaks.

8. Lunar craters are usually named after scientists and explorers. One of the craters on the Moon is named after a prominent scientist in the field of mass spectrometry. Who is named after?

9. Who first reported the fragmentation after the gamma hydrogen rearrangement to an unsaturated group via a sixmembered intermediate?

10. The first on-line coupling of gas chromatography to a mass spectrometer was reported in 1959. What type of spectrometer was used for this purpose?

Czech Museumof Mass Spectrometry

Our partners

1.
Who made molecular elephants fly?

2.
List these compounds according to their increasing mass: hydrazine (H4N2), oxygen (O2), methanol (CH4O).

3.
The quadrupole mass filter has been known since the mid-1950s thanks to the work of Wolfgang Paul. The motion of ions in a quadrupole field can be described by solving second-order differential equations. When were these equations solved mathematically?

4.
Which element has the largest number of stable isotopes?

5.
John Zeleny was an American physicist whose work laid the theoretical foundations of electrospray ionization. He was born in 1872 into a family of immigrants from Europe. Where did his family come from?

6.
Which mass spectrometer was carried by the American spacecraft Viking 1 sent to the planet Mars in 1975?

7.
How long would be a paper needed for printing a profile mass spectrum measured in the m/z 0 1000 range at a resolution of 50,000 at m/z 500 if the peaks were to be 1 mm wide at their half maximum? Let us consider a constant width of all peaks.

8.
Lunar craters are usually named after scientists and explorers. One of the craters on the Moon is named after a prominent scientist in the field of mass spectrometry. Who is named after?

9.
Who first reported the fragmentation after the gamma hydrogen rearrangement to an unsaturated group via a sixmembered intermediate?

10.
The first on-line coupling of gas chromatography to a mass spectrometer was reported in 1959. What type of spectrometer was used for this purpose?

Czech Museum
of Mass Spectrometry