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Mass Spectrometry Quiz

Mass Spectrometry Quiz

Test your knowledge on mass spectrometry and its history

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  • 1.
    Joseph John Thomson (1856 - 1940), Nobel laureate in physics, is credited with the invention of the mass spectrometer, the discovery of the electron and isotopes of stable elements. A lesser-known fact is his father's profession. What was it?

    Your answer:
    Correct answer:

    His father, Joseph James Thomson, ran an antiquarian bookshop founded by Thomson’s great-grandfather. [Wikipedia]

  • 2.
    What is the electric charge of an ion with m/z = m?

    Your answer:
    Correct answer:

    The particle carries one elementary charge, the value of which is 1.602 176 634 × 10−19 C (exactly).

  • 3.
    Who first reported the fragmentation after the gamma hydrogen rearrangement to an unsaturated group via a sixmembered intermediate?

    Your answer:
    Correct answer:
    It was first reported by Australian A. J. C. Nicholson in 1954 (Trans. Faraday Soc. 50: 1067-1073). The reaction description was published five years later (Anal. Chem. 1959, 31: 82–87) by the American chemist Fred McLafferty, by whose name we now refer to the rearrangement (McLafferty rearrangement).
  • 4.
    Until 2019, the kilogram unit was defined using an international prototype kept at the International Bureau of Weights and Measures in France. The International Prototype of the Kilogram was made of an alloy of platinum and one other metal. The metal was:

    Your answer:
    Correct answer:

    The International Prototype of the Kilogram was a cylinder with a height and diameter of 39 mm made of an alloy of 90% platinum and 10% iridium.

  • 5.
    Who built the first mass spectrometer in Czechia?

    Your answer:
    Correct answer:

    The first mass spectrometer in the country was built in the Laboratory of Physical Chemistry of the Czechoslovak Academy of Sciences. Four young scientists, Vladimír Čermák, Vladimír Hanuš, Čestmír Jech and Josef Cabicar, took part in its construction. At the time of the post-war shortage, it was very difficult to find the necessary components; some parts originated from captured German military equipment. The mass spectrometer was of the Nier type with simple focusing and 60° magnetic field, pumped by a mercury diffusion pump. The device was completed after two years, in 1953. The construction of this instrument was an extraordinary achievement awarded a year later by the State Prize. [Z. Herman, Chem. Listy 104, 955, 2010]

  • 6.
    What is the trajectory of a charged particle moving parallel to a uniform electric field in a vacuum?

    Your answer:
    Correct answer:

    If a positive charge is moving in the same direction as the electric field vector the particle's velocity will increase. If it is moving in the opposite direction it will decelerate. If a negative charge is moving in the same direction as the electric field vector the particle will decelerate. If it is moving in the opposite direction it will accelerate.

  • 7.
    Lunar craters are usually named after scientists and explorers. One of the craters on the Moon is named after a prominent scientist in the field of mass spectrometry. Who is named after?

    Your answer:
    Correct answer:

    Aston is a 44-kilometer lunar impact crater located along the northwestern limb of the Moon. The crater was named in honor of Francis W. Aston.

  • 8.
    List these compounds according to their increasing mass: hydrazine (H4N2), oxygen (O2), methanol (CH4O).

    Your answer:
    Correct answer:

    The monoisotopic masses of these compounds are 31.989829 Da (oxygen), 32.026215 Da (methanol), and 32.037448 Da (hydrazine).

  • 9.
    What was the largest number of quadrupoles connected in series for tandem mass spectrometry in a commercial instrument?

    Your answer:
    Correct answer:
    A penta-quadrupole mass spectrometer contains three quadrupole filters and two rf-only quadrupole collision cells. It allows MS3 experiments.  Extrel once offered such a spectrometer.
  • 10.
    The quadrupole mass filter has been known since the mid-1950s thanks to the work of Wolfgang Paul. The motion of ions in a quadrupole field can be described by solving second-order differential equations. When were these equations solved mathematically?

    Your answer:
    Correct answer:

    The solution of differential equations of this type came from the French mathematician Émile Léonard Mathieu (1835-1890), who studied the mechanical vibrations of the elliptical drumheads.

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