Mass Spectrometry Quiz

1.
How long would be a paper needed for printing a profile mass spectrum measured in the m/z 0 1000 range at a resolution of 50,000 at m/z 500 if the peaks were to be 1 mm wide at their half maximum? Let us consider a constant width of all peaks.
- 1 m
- 10 m
- 100 m
Your answer:

Correct answer:

The resolution can be expressed as (m/z)/Δ(m/z), where Δ (m/z) is the peak width at 50 % of its maximum. For a resolution of 50,000 at m/z 500, the value of Δ(m/z) is 0.01. If the Δ(m/z) is to correspond to 1 mm, then the total width of the spectral record equals 1000/0.01 mm, which is 100,000 mm, which is 100 m.
2.
Who first reported the fragmentation after the gamma hydrogen rearrangement to an unsaturated group via a sixmembered intermediate?
- A. J. C. Nicholson
- F. W. McLafferty
- F. Tureček
Your answer:

Correct answer:

It was first reported by Australian A. J. C. Nicholson in 1954 (Trans. Faraday Soc. 50: 1067-1073). The reaction description was published five years later (Anal. Chem. 1959, 31: 82–87) by the American chemist Fred McLafferty, by whose name we now refer to the rearrangement (McLafferty rearrangement).
3.
What is the trajectory of a charged particle moving perpendicularly to a uniform magnetic field in a vacuum?
- The particle follows a curved path and continues to follow this path until it forms a complete circle
- The particle follows a helical path
- The particle follows a straight line and accelerates
Your answer:

Correct answer:

The magnetic force is perpendicular to the velocity so that it does no work on the charged particle. The particle’s kinetic energy and speed thus remain constant. The direction of motion is affected but not the speed.
4.
List these compounds according to their increasing mass: hydrazine (H4N2), oxygen (O2), methanol (CH4O).
- Hydrazine, oxygen, methanol
- Methanol, hydrazine, oxygen
- Oxygen, methanol, hydrazine
Your answer:

Correct answer:

The monoisotopic masses of these compounds are 31.989829 Da (oxygen), 32.026215 Da (methanol), and 32.037448 Da (hydrazine).
5.
Chemical ionization (CI) is a soft ionization technique used in mass spectrometry. Who discovered it?
- Burnaby Munson and Frank H. Field
- Michael Barber
- Hans-Dieter Beckey
Your answer:

Correct answer:

Chemical ionization was discovered in the laboratories of the Humble Oil and Refining Company in Baytown, TX. Munson and Field’s seminal paper on chemical ionization was published in 1966. [https://doi.org/10.1021/ja00964a001]
6.
What is the electric charge of an ion with m/z = m?
- 1 C
- 1.602 176 634 x 10^-19 C
- 1 eV
Your answer:

Correct answer:

The particle carries one elementary charge, the value of which is 1.602 176 634 × 10⁻¹⁹ C (exactly).
7.
Until 2019, the kilogram unit was defined using an international prototype kept at the International Bureau of Weights and Measures in France. The International Prototype of the Kilogram was made of an alloy of platinum and one other metal. The metal was:
- Gold
- Iridium
- Rhenium
Your answer:

Correct answer:

The International Prototype of the Kilogram was a cylinder with a height and diameter of 39 mm made of an alloy of 90% platinum and 10% iridium.
8.
The quadrupole mass filter has been known since the mid-1950s thanks to the work of Wolfgang Paul. The motion of ions in a quadrupole field can be described by solving second-order differential equations. When were these equations solved mathematically?
- 1868
- 1968
- 1989
Your answer:

Correct answer:

The solution of differential equations of this type came from the French mathematician Émile Léonard Mathieu (1835-1890), who studied the mechanical vibrations of the elliptical drumheads.
9.
The first on-line coupling of gas chromatography to a mass spectrometer was reported in 1959. What type of spectrometer was used for this purpose?
- Double-focusing mass spectrometer
- Time-of-flight mass spectrometer
- Quadrupole mass spectrometer
Your answer:

Correct answer:

The first GC/MS experiments were carried out by Fred McLafferty and Roland Gohlke at Dow Chemical with Bill Wiley and Ian McLaren at Bendix Research Laboratories. They used a Bendix timeof- flight mass spectrometer, which had been commercially introduced in 1956. The instrument was fast enough to keep up with the changing output of the GC column.
10.
John Zeleny was an American physicist whose work laid the theoretical foundations of electrospray ionization. He was born in 1872 into a family of immigrants from Europe. Where did his family come from?
- Slovakia
- Czechia
- Poland
Your answer:

Correct answer:

The parents of John Zelený, Antonín Zelený and Josefa Pitková, came from Křídla, a small village near Žďár nad Sázavou in Austria-Hungary (now the Czech Republic).

Mass Spectrometry Quiz

Mass Spectrometry Quiz

Thank you for taking our quiz!

1.
How long would be a paper needed for printing a profile mass spectrum measured in the m/z 0 1000 range at a resolution of 50,000 at m/z 500 if the peaks were to be 1 mm wide at their half maximum? Let us consider a constant width of all peaks.

2.
Who first reported the fragmentation after the gamma hydrogen rearrangement to an unsaturated group via a sixmembered intermediate?

3.
What is the trajectory of a charged particle moving perpendicularly to a uniform magnetic field in a vacuum?

4.
List these compounds according to their increasing mass: hydrazine (H4N2), oxygen (O2), methanol (CH4O).

5.
Chemical ionization (CI) is a soft ionization technique used in mass spectrometry. Who discovered it?

6.
What is the electric charge of an ion with m/z = m?

7.
Until 2019, the kilogram unit was defined using an international prototype kept at the International Bureau of Weights and Measures in France. The International Prototype of the Kilogram was made of an alloy of platinum and one other metal. The metal was:

8.
The quadrupole mass filter has been known since the mid-1950s thanks to the work of Wolfgang Paul. The motion of ions in a quadrupole field can be described by solving second-order differential equations. When were these equations solved mathematically?

9.
The first on-line coupling of gas chromatography to a mass spectrometer was reported in 1959. What type of spectrometer was used for this purpose?

10.
John Zeleny was an American physicist whose work laid the theoretical foundations of electrospray ionization. He was born in 1872 into a family of immigrants from Europe. Where did his family come from?

Czech Museum
of Mass Spectrometry

Our partners

Mass Spectrometry Quiz

Mass Spectrometry Quiz

Thank you for taking our quiz!

1. How long would be a paper needed for printing a profile mass spectrum measured in the m/z 0 1000 range at a resolution of 50,000 at m/z 500 if the peaks were to be 1 mm wide at their half maximum? Let us consider a constant width of all peaks.

2. Who first reported the fragmentation after the gamma hydrogen rearrangement to an unsaturated group via a sixmembered intermediate?

3. What is the trajectory of a charged particle moving perpendicularly to a uniform magnetic field in a vacuum?

4. List these compounds according to their increasing mass: hydrazine (H4N2), oxygen (O2), methanol (CH4O).

5. Chemical ionization (CI) is a soft ionization technique used in mass spectrometry. Who discovered it?

6. What is the electric charge of an ion with m/z = m?

7. Until 2019, the kilogram unit was defined using an international prototype kept at the International Bureau of Weights and Measures in France. The International Prototype of the Kilogram was made of an alloy of platinum and one other metal. The metal was:

8. The quadrupole mass filter has been known since the mid-1950s thanks to the work of Wolfgang Paul. The motion of ions in a quadrupole field can be described by solving second-order differential equations. When were these equations solved mathematically?

9. The first on-line coupling of gas chromatography to a mass spectrometer was reported in 1959. What type of spectrometer was used for this purpose?

10. John Zeleny was an American physicist whose work laid the theoretical foundations of electrospray ionization. He was born in 1872 into a family of immigrants from Europe. Where did his family come from?

Czech Museumof Mass Spectrometry

Our partners

1.
How long would be a paper needed for printing a profile mass spectrum measured in the m/z 0 1000 range at a resolution of 50,000 at m/z 500 if the peaks were to be 1 mm wide at their half maximum? Let us consider a constant width of all peaks.

2.
Who first reported the fragmentation after the gamma hydrogen rearrangement to an unsaturated group via a sixmembered intermediate?

3.
What is the trajectory of a charged particle moving perpendicularly to a uniform magnetic field in a vacuum?

4.
List these compounds according to their increasing mass: hydrazine (H4N2), oxygen (O2), methanol (CH4O).

5.
Chemical ionization (CI) is a soft ionization technique used in mass spectrometry. Who discovered it?

6.
What is the electric charge of an ion with m/z = m?

7.
Until 2019, the kilogram unit was defined using an international prototype kept at the International Bureau of Weights and Measures in France. The International Prototype of the Kilogram was made of an alloy of platinum and one other metal. The metal was:

8.
The quadrupole mass filter has been known since the mid-1950s thanks to the work of Wolfgang Paul. The motion of ions in a quadrupole field can be described by solving second-order differential equations. When were these equations solved mathematically?

9.
The first on-line coupling of gas chromatography to a mass spectrometer was reported in 1959. What type of spectrometer was used for this purpose?

10.
John Zeleny was an American physicist whose work laid the theoretical foundations of electrospray ionization. He was born in 1872 into a family of immigrants from Europe. Where did his family come from?

Czech Museum
of Mass Spectrometry